Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of CD38+ and CD38- cells derived from the same CLL patient reveals distinct gene expression signatures despite their monoclonal origin.

ABSTRACT: CD38 expression is an important prognostic marker in CLL with high levels of CD38 associated with shorter overall survival. In this study, we used gene expression profiling and protein analysis of highly purified cell-sorted CD38+ and CD38- chronic lymphocytic leukemia cells to elucidate a molecular basis for the association between CD38 expression and inferior clinical outcome. Paired CD38+ and CD38- CLL cells derived from the same patient were shown to be monoclonal by VH gene sequencing but despite this, CD38+ CLL cells possessed a distinct gene expression profile when compared with their CD38- sub-clones. Experiment Overall Design: These experiments compared the gene expression profile of CD38+ and CD38- sub-clones derived from 6 individual CLL patients.

ORGANISM(S): Homo sapiens

SUBMITTER: Chris Pepper 

PROVIDER: E-GEOD-6321 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Highly purified CD38+ and CD38- sub-clones derived from the same chronic lymphocytic leukemia patient have distinct gene expression signatures despite their monoclonal origin.

Pepper C C   Ward R R   Lin T T TT   Brennan P P   Starczynski J J   Musson M M   Rowntree C C   Bentley P P   Mills K K   Pratt G G   Fegan C C  

Leukemia 20070208 4

CD38 expression is an important prognostic marker in chronic lymphocytic leukemia (CLL) with high levels of CD38 associated with shorter overall survival. In this study, we used gene expression profiling and protein analysis of highly purified cell-sorted CD38(+) and CD38(-) chronic lymphocytic leukemia cells to elucidate a molecular basis for the association between CD38 expression and inferior clinical outcome. Paired CD38(+) and CD38(-) CLL cells derived from the same patient were shown to be  ...[more]

Similar Datasets

Transcriptomics Analysis of CD38+ and CD38- sub-clones derived from the same CLL patient
2006-11-23 | GSE6321 | GEO
Transcriptomics CLL: CD38+CD49d+ vs. CD38-CD49d-
2009-03-03 | GSE14560 | GEO
Transcriptomics Expression data from native ZAP-70+CD38+ vs. ZAP-70-CD38- CLL cells
2006-09-22 | GSE4392 | GEO
Transcriptomics Transcription profiling of human ZAP-70+CD38+ and ZAP-70-CD38- B-cells from chronic lymphocytic leukemia patients
2009-04-23 | E-GEOD-4392 | biostudies-arrayexpress
Transcriptomics The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting
2014-04-01 | E-GEOD-56369 | biostudies-arrayexpress
Genomics Homo sapiens
| PRJNA100583 | ENA
Transcriptomics The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting
2014-04-01 | GSE56369 | GEO
Transcriptomics CD38 modulates CXCR4 signals in chronic lymphocytic leukemia cells: potential therapeutic implications
2009-12-22 | GSE14063 | GEO
Transcriptomics RNA-seq of variable heavy and light IgG fragments of CD19(+)CD24(high)CD38(high) subpopulation isolated from peripheral blood of patients with multiple sclerosis and healthy donors.
2020-09-24 | E-MTAB-9573 | biostudies-arrayexpress
Other TCR repertoire of effector CCR7-CD38+ cells accumulating during experimental infection with Typhoidal Salmonella
2018-05-13 | GSE113112 | GEO