Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Expression profiling of T.rubrum treated with PH11B

ABSTRACT: T. rubrum was treated with PH11B,a potent eucaryotic fatty acid synthase inhibtor. A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to PH11B were determined. Some class-specific and mechanism-independent changes in gene expression were found. Keywords: fatty acid synthase inhibition The expression profiles of Trichophyton rubrum treated with PH11B were compared to those of Trichophyton rubrum without drug. Each treatment has three replicates.

ORGANISM(S): Trichophyton rubrum

SUBMITTER: Qi Jin

PROVIDER: E-GEOD-6336 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Global gene expression of Trichophyton rubrum in response to PH11B, a novel fatty acid synthase inhibitor.

Yu L L Zhang W W Liu T T Wang X X Peng J J Li S S Jin Q Q

Journal of applied microbiology 20071201 6

<h4>Aims</h4>To determine the transcriptional responses of Trichophyton rubrum to the artificial substance, PH11B.<h4>Methods and results</h4>The broth microdilution assay for antifungal susceptibility testing of dermatophytes was used to measure the minimum inhibitory concentration (MIC) of PH11B. cDNA microarray technology and real-time RT-PCR were used to study the transcriptional responses of T. rubrum to PH11B. The MIC determined was 16 microg ml(-1). The analysis of microarray data reveale ...[more]

PMID: 18045420

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Dataset Information

Expression profiling of T.rubrum treated with PH11B

Publications

Global gene expression of Trichophyton rubrum in response to PH11B, a novel fatty acid synthase inhibitor.

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