Ontology highlight
ABSTRACT:
ORGANISM(S): Macaca fascicularis
SUBMITTER: Naoomi Tominaga
PROVIDER: E-GEOD-63447 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Tominaga Naoomi N Kosaka Nobuyoshi N Ono Makiko M Katsuda Takeshi T Yoshioka Yusuke Y Tamura Kenji K Lötvall Jan J Nakagama Hitoshi H Ochiya Takahiro T
Nature communications 20150401
Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain metastasis is the migration of cancer cells through blood-brain barrier (BBB). However, the molecular mechanism behind the passage through this natural barrier remains unclear. Here we show that cancer-derived extracellular vesicles (EVs), mediators of cell-cell communication via delivery of proteins and microRNAs (miRNAs), trigger the breakdown of BBB. Importantly, miR-181c promotes the destr ...[more]