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Tbr2 and Neurog2 occupancy and transcriptional profiling of control and Tbr2 knockout E14.5 cerebral cortices

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Luca Massimino

PROVIDER: E-GEOD-63621 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.

Sessa Alessandro A Ciabatti Ernesto E Drechsel Daniela D Massimino Luca L Colasante Gaia G Giannelli Serena S Satoh Takashi T Akira Shizuo S Guillemot Francois F Broccoli Vania V

Cerebral cortex (New York, N.Y. : 1991) 20170601 6

The T-box containing Tbr2 gene encodes for a transcription factor essential for the specification of the intermediate neural progenitors (INPs) originating the excitatory neurons of the cerebral cortex. However, its overall mechanism of action, direct target genes and cofactors remain unknown. Herein, we carried out global gene expression profiling combined with genome-wide binding site identification to determine the molecular pathways regulated by TBR2 in INPs. This analysis led to the identif ...[more]

PMID: 27600842

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