Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Oliver Sieber
PROVIDER: E-GEOD-63624 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jorissen Robert N RN Christie Michael M Mouradov Dmitri D Sakthianandeswaren Anuratha A Li Shan S Love Christopher C Xu Zheng-Zhou ZZ Molloy Peter L PL Jones Ian T IT McLaughlin Stephen S Ward Robyn L RL Hawkins Nicholas J NJ Ruszkiewicz Andrew R AR Moore James J Burgess Antony W AW Busam Dana D Zhao Qi Q Strausberg Robert L RL Lipton Lara L Desai Jayesh J Gibbs Peter P Sieber Oliver M OM
British journal of cancer 20150825 6
<h4>Background</h4>APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear.<h4>Methods</h4>APC prognostic value was evaluated in 746 stage I-IV CRC patients, stratifying for tumour location and microsatellite instability (MSI). Microarrays were used to identify a gene signature that could classify APC mutation status, and classifier ability to predict prognosis was examined in an independent cohort.<h4>Results</h4>Wild-type APC microsatel ...[more]