Unknown,Transcriptomics,Genomics,Proteomics

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Expression data for 52 microsatellite stable (MSS) primary tumors from patients with proximal colon cancer.


ABSTRACT: Samples were taken from surgically resected tumor specimens from patients with proximal colon cancer. The expression profiles were determined using the Affymetrix GeneChip Human Exon 1.0 ST Array version 2. APC gene mutation status was determined using Sanger sequencing. A classifier for APC mutation status was trained using these expression data. 52 microsatellite stable (MSS) proximal colon cancers samples were analyzed. 17 samples were APC wild-type and 35 had APC protein-truncating mutations.

ORGANISM(S): Homo sapiens

SUBMITTER: Oliver Sieber 

PROVIDER: E-GEOD-63624 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Background</h4>APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear.<h4>Methods</h4>APC prognostic value was evaluated in 746 stage I-IV CRC patients, stratifying for tumour location and microsatellite instability (MSI). Microarrays were used to identify a gene signature that could classify APC mutation status, and classifier ability to predict prognosis was examined in an independent cohort.<h4>Results</h4>Wild-type APC microsatel  ...[more]

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