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Epigenomic landscape during organ formation in human early embryos

ABSTRACT: Here we present the whole genome ChIP-Seq analyses of a wide variety of histone marks, H3K27ac, H3K4me1, H3K4me3, and H3K27me3 in the brain, heart, and liver, along with the RNA-seq data of these organs of early human embryos 12 weeks after gestation. In total, brain, heart, and liver of early human post-implantation embryos were used, and four histone modifications were detected, including H3K27ac, H3K4me1, H3K4me3 and H3K27me3. Also, the transcriptomes of these three organs were analyzed.

ORGANISM(S): Homo sapiens

SUBMITTER: Hongshan Guo

PROVIDER: E-GEOD-63634 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epigenomic Landscape of Human Fetal Brain, Heart, and Liver.

Yan Liying L Guo Hongshan H Hu Boqiang B Li Rong R Yong Jun J Zhao Yangyu Y Zhi Xu X Fan Xiaoying X Guo Fan F Wang Xiaoye X Wang Wei W Wei Yuan Y Wang Yan Y Wen Lu L Qiao Jie J Tang Fuchou F

The Journal of biological chemistry 20151230 9

The epigenetic regulation of spatiotemporal gene expression is crucial for human development. Here, we present whole-genome chromatin immunoprecipitation followed by high throughput DNA sequencing (ChIP-seq) analyses of a wide variety of histone markers in the brain, heart, and liver of early human embryos shortly after their formation. We identified 40,181 active enhancers, with a large portion showing tissue-specific and developmental stage-specific patterns, pointing to their roles in control ...[more]

PMID: 26719341

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