Unknown,Transcriptomics,Genomics,Proteomics

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ChIP-seq of MYST acetyltransferases in RKO cell line


ABSTRACT: Genome-wide mapping of MYST acetyltransferase subunit BRPF3 in RKO synchronised cells. Genome-wide mapping of MYST acetyltransferase subunit BRPF3 in RKO synchronised cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Paquet 

PROVIDER: E-GEOD-63722 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


During DNA replication, thousands of replication origins are activated across the genome. Chromatin architecture contributes to origin specification and usage, yet it remains unclear which chromatin features impact on DNA replication. Here, we perform a RNAi screen for chromatin regulators implicated in replication control by measuring RPA accumulation upon replication stress. We identify six factors required for normal rates of DNA replication and characterize a function of the bromodomain and  ...[more]

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