Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Eric Paquet
PROVIDER: E-GEOD-63722 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Feng Yunpeng Y Vlassis Arsenios A Roques Céline C Lalonde Marie-Eve ME González-Aguilera Cristina C Lambert Jean-Philippe JP Lee Sung-Bau SB Zhao Xiaobei X Alabert Constance C Johansen Jens V JV Paquet Eric E Yang Xiang-Jiao XJ Gingras Anne-Claude AC Côté Jacques J Groth Anja A
The EMBO journal 20151130 2
During DNA replication, thousands of replication origins are activated across the genome. Chromatin architecture contributes to origin specification and usage, yet it remains unclear which chromatin features impact on DNA replication. Here, we perform a RNAi screen for chromatin regulators implicated in replication control by measuring RPA accumulation upon replication stress. We identify six factors required for normal rates of DNA replication and characterize a function of the bromodomain and ...[more]