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Synergism between PPAR? and glucocorticoid receptor signaling promotes self-renewal of BFU-E erythroid progenitors and increases red cell production [RNA-seq]

ABSTRACT: Analyses of gene expression by RNA-Seq in mouse E14.5 fetal liver burst-forming unit erythroid (BFU-E) cells untreated or treated by dexamethasone (DEX) with or without PPAR? agonist GW7647. RNA-Seq was performed on enriched populations of mouse BFU-E isolated from E14.5 fetal liver, as well as BFU-E enriched cells treated with Dex ± GW7647.

ORGANISM(S): Mus musculus

SUBMITTER: Xiaofei Gao

PROVIDER: E-GEOD-63836 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal.

Lee Hsiang-Ying HY Gao Xiaofei X Barrasa M Inmaculada MI Li Hu H Elmes Russell R RR Peters Luanne L LL Lodish Harvey F HF

Nature 20150511 7557

Many acute and chronic anaemias, including haemolysis, sepsis and genetic bone marrow failure diseases such as Diamond-Blackfan anaemia, are not treatable with erythropoietin (Epo), because the colony-forming unit erythroid progenitors (CFU-Es) that respond to Epo are either too few in number or are not sensitive enough to Epo to maintain sufficient red blood cell production. Treatment of these anaemias requires a drug that acts at an earlier stage of red cell formation and enhances the formatio ...[more]

PMID: 25970251

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