Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Analysis of wildtype and Csnk2b-deficient Foxp3+ regulatory T cells transcriptomes

ABSTRACT: The goal of this study was to compare the transcriptional changes evoked by Csnk2b-deficiency in Foxp3+ regulatory T cells Messenger RNA profiles of CD4+Foxp3+ regulatory T cells isolated from 8 week old wild type (WT) and Csnk2b-deficient mice were generated by deep sequencing in duplicate, using Illumina MiSeq

ORGANISM(S): Mus musculus

SUBMITTER: Tobias Bopp

PROVIDER: E-GEOD-63961 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.

Ulges Alexander A Klein Matthias M Reuter Sebastian S Gerlitzki Bastian B Hoffmann Markus M Grebe Nadine N Staudt Valérie V Stergiou Natascha N Bohn Toszka T Brühl Till-Julius TJ Muth Sabine S Yurugi Hajime H Rajalingam Krishnaraj K Bellinghausen Iris I Tuettenberg Andrea A Hahn Susanne S Reißig Sonja S Haben Irma I Zipp Frauke F Waisman Ari A Probst Hans-Christian HC Beilhack Andreas A Buchou Thierry T Filhol-Cochet Odile O Boldyreff Brigitte B Breloer Minka M Jonuleit Helmut H Schild Hansjörg H Schmitt Edgar E Bopp Tobias T

Nature immunology 20150119 3

The quality of the adaptive immune response depends on the differentiation of distinct CD4(+) helper T cell subsets, and the magnitude of an immune response is controlled by CD4(+)Foxp3(+) regulatory T cells (Treg cells). However, how a tissue- and cell type-specific suppressor program of Treg cells is mechanistically orchestrated has remained largely unexplored. Through the use of Treg cell-specific gene targeting, we found that the suppression of allergic immune responses in the lungs mediated ...[more]

PMID: 25599562

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Project description:We found that assassin bugs from the earliest-diverging subfamily of higher Reduviidae (Peiratinae), as well as a subfamily closely related to Triatominae (Stenopodainae) have venom that is highly similar in composition to that produced by previously examined reduviids from Harpactorinae and Reduviinae. This finding suggests that venom composition has been largely stable due to purifying selection among the higher Reduviidae, which is consistent with the ancient origin of venom in the ancestors of Heteroptera 250–300 million years ago (Sunagar and Moran 2015; Walker et al. 2018a). This near homogeneity of venom composition is perhaps surprising considering that reduviid predators have evolved numerous instances of prey specialization and specialized hunting strategies that might be expected to co-evolve with venom. Possibly, further studies focussing on species with more specialized hunting strategies, or different kinds of venom bioactivities, will uncover more nuanced venom adaptations. Alternatively, it is possible that the protease-rich venoms of predatory reduviids are simply well-suited to myriad different hunting strategies. These data are consistent with other examples where venoms are surprisingly similar despite great differences in biology, for example between solitary and eusocial bees. A more detailed picture of venom evolution in Reduviidae would examine venom produced by the early-diverging Phymatine complex as well as venoms of non-reduviid cimicomorphs, prey specialists such as the arachnophagous Emesinae and the myrmecophagous Holoptilinae, and some of the many groups that employ hunting specializations, such as the use of plant resins to catch prey (Hwang and Weirauch 2012). Within Triatominae, examination of saliva produced by additional species from multiple lineages (especially those that switched to blood-feeding independently, if the subfamily is shown to be polyphyletic) and including generalists and specialists on different host taxa and species associated especially with nests and burrows will be informative. The venoms of predatory reduviids such as Zelurus spp. and Opisthacidius spp. that are most closely related to Triatominae, and share some behaviours such as habitation of bird nests by Opisthacidius spp. may also provide more information about the evolution of triatomine saliva.

Dataset Information

Analysis of wildtype and Csnk2b-deficient Foxp3+ regulatory T cells transcriptomes

Publications

Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.

Similar Datasets

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