Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ichiro Nakano
PROVIDER: E-GEOD-63963 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kim Sung-Hak SH Joshi Kaushal K Ezhilarasan Ravesanker R Myers Toshia R TR Siu Jason J Gu Chunyu C Nakano-Okuno Mariko M Taylor David D Minata Mutsuko M Sulman Erik P EP Lee Jeongwu J Bhat Krishna P L KP Salcini Anna Elisabetta AE Nakano Ichiro I
Stem cell reports 20150115 2
Glioblastoma (GBM)-derived tumorigenic stem-like cells (GSCs) may play a key role in therapy resistance. Previously, we reported that the mitotic kinase MELK binds and phosphorylates the oncogenic transcription factor FOXM1 in GSCs. Here, we demonstrate that the catalytic subunit of Polycomb repressive complex 2, EZH2, is targeted by the MELK-FOXM1 complex, which in turn promotes resistance to radiation in GSCs. Clinically, EZH2 and MELK are coexpressed in GBM and significantly induced in postir ...[more]