Transcription profiling of heart from Lmna H222P homozygous and control mice

ABSTRACT: The present research is devoted to the identification of gene(s) severely affected by LMNA mutations, leading to striated muscle laminopathies and more specifically the cardiomyopathy. For this purpose, we developped a large-scale gene expression approach on heart and skeletal tissues from Lmna H222P heterozygous Knock-In mouse model. Experiment Overall Design: In the project presented here we performed differential expression in heart from a mouse model of EDMD: a LmnaH222P knock-in mouse created via homologous recombination by Gisele Bonne in Paris, France (Arimura et al., 2005). The mutant male LmnaH222P knock-in homozygous mice display reduced locomotion activity with abnormal stiff walking posture and all of them die by 9 months of age. As for cardiac phenotype, they develop chamber d

ORGANISM(S): Mus musculus

SUBMITTER: antoine Muchir 

PROVIDER: E-GEOD-6398 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress