Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Expression data from ileum of mice suffered from subchronic and mild social defeat stress

ABSTRACT: This study aimed to investigate the effects of depression on transcriptome in ileum using a subchronic and mild social defeat stress (sCSDS) model. In addition to exhibiting social deficit and hyperphagia-like behavior, the sCSDS mice keep much more water in their body than control mice. In order to investigate the effect of social defeat stress on not only central nervous system but also function of gastrointestinal tract, the gene expression in ileum of stressed mice was compared with control mice. We used microarrays to detail the gene expression after 10 days of social defeat stress and identified distinct classes of down-regulated genes during this process. The duration of physical contacts was set at 5 min after the first attack bite at Day 1, and then was reduced 0.5 min per day from Day 2 to Day 10.

ORGANISM(S): Mus musculus

SUBMITTER: Chise Suzuki

PROVIDER: E-GEOD-64004 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Omics Studies of the Murine Intestinal Ecosystem Exposed to Subchronic and Mild Social Defeat Stress.

Aoki-Yoshida Ayako A Aoki Reiji R Moriya Naoko N Goto Tatsuhiko T Kubota Yoshifumi Y Toyoda Atsushi A Takayama Yoshiharu Y Suzuki Chise C

Journal of proteome research 20160815 9

The microbiota-gut-brain axis plays an important role in the development of stress-induced mental disorders. We previously established the subchronic and mild social defeat stress (sCSDS) model, a murine experimental model of depression, and investigated the metabolomic profiles of plasma and liver. Here we used omics approaches to identify stress-induced changes in the gastrointestinal tract. Mice exposed to sCSDS for 10 days showed the following changes: (1) elevation of cholic acid and reduct ...[more]

PMID: 27482843

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Dataset Information

Expression data from ileum of mice suffered from subchronic and mild social defeat stress

Publications

Omics Studies of the Murine Intestinal Ecosystem Exposed to Subchronic and Mild Social Defeat Stress.

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