Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Manoj Bhasin
PROVIDER: E-GEOD-64052 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhang Liang L Wang Xiaoen X Bullock Andrea J AJ Callea Marcella M Shah Harleen H Song Jiaxi J Moreno Kelli K Visentin Barbara B Deutschman Douglas D Alsop David C DC Atkins Michael B MB Mier James W JW Signoretti Sabina S Bhasin Manoj M Sabbadini Roger A RA Bhatt Rupal S RS
Clinical cancer research : an official journal of the American Association for Cancer Research 20150114 8
<h4>Purpose</h4>VEGFR2 tyrosine kinase inhibition (TKI) is a valuable treatment approach for patients with metastatic renal cell carcinoma (RCC). However, resistance to treatment is inevitable. Identification of novel targets could lead to better treatment for patients with TKI-naïve or -resistant RCC.<h4>Experimental design</h4>In this study, we performed transcriptome analysis of VEGFR TKI-resistant tumors in a murine model and discovered that the SPHK-S1P pathway is upregulated at the time of ...[more]