Patterns of somatic uniparental disomy identify driver tumor suppressor genes in colorectal cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jordi Camps
PROVIDER: E-GEOD-64114 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer.
Torabi Keyvan K Miró Rosa R Fernández-Jiménez Nora N Quintanilla Isabel I Ramos Laia L Prat Esther E del Rey Javier J Pujol Núria N Killian J Keith JK Meltzer Paul S PS Fernández Pedro Luis PL Ried Thomas T Lozano Juan José JJ Camps Jordi J Ponsa Immaculada I
Carcinogenesis 20150804 10
Colorectal cancer (CRC) is characterized by specific patterns of copy number alterations (CNAs), which helped with the identification of driver oncogenes and tumor suppressor genes (TSGs). More recently, the usage of single nucleotide polymorphism arrays provided information of copy number neutral loss of heterozygosity, thus suggesting the occurrence of somatic uniparental disomy (UPD) and uniparental polysomy (UPP) events. The aim of this study is to establish an integrative profiling of recur ...[more]
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