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Expression data of worms under different caloric restriction mimetic treatments

ABSTRACT: We used microarray analysis to further our understanding of the mode of action of the well know caloric restriction mimetic rapamycin and the compound Allantoin first studied in the context of aging in this study. His work helps build on our understanding of potential caloric restriction mimetics predicted from our bioinformatic aproach of quering the Connectivity Map, a database of drug-induced gene expression profiles, using the transcriptional profile of CR to identify drugs that induce a similar or opposite gene expression profile. Wild type worms of eat-2 mutants (a model of caloric restriction) were treated with the compounds of study with 2% DMSO or DMSO alone to serve as controls. All samples were peformed in triplicate.

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: João Pedro de Magalhães 

PROVIDER: E-GEOD-64336 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans.

Calvert Shaun S   Tacutu Robi R   Sharifi Samim S   Teixeira Rute R   Ghosh Pratul P   de Magalhães João Pedro JP  

Aging cell 20151216 2

Caloric restriction (CR), a reduction in calorie intake without malnutrition, retards aging in several animal models from worms to mammals. Developing CR mimetics, compounds that reproduce the longevity benefits of CR without its side effects, is of widespread interest. Here, we employed the Connectivity Map to identify drugs with overlapping gene expression profiles with CR. Eleven statistically significant compounds were predicted as CR mimetics using this bioinformatics approach. We then test  ...[more]

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