Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

RNA-Induced Silencing Complex-associated RNA in MRC-5 cells transfected with hcmv-miR-UL22A-5p

ABSTRACT: Investigation of mRNA targets of the human cytomegalovirus miRNA UL22A-5p One 4-plex chip was hybridized with cDNA originating from either total RNA or from AGO2-associated RNA (i.e. RISC-associated RNA) from fibroblasts transfected 48 hours earlier with hcmv-miR-UL22A-5p mimic or with a negative control siRNA

ORGANISM(S): Homo sapiens

SUBMITTER: Luiz Lisboa

PROVIDER: E-GEOD-64503 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hcmv-miR-UL22A-5p: A Biomarker in Transplantation With Broad Impact on Host Gene Expression and Potential Immunological Implications.

Lisboa L F LF Egli A A O'Shea D D Åsberg A A Hartmann A A Rollag H H Pang X L XL Tyrrell D L DL Kumar D D Humar A A

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20150401 7

Cytomegalovirus (CMV) encodes multiple microRNAs. While these have been partially characterized in vitro, their relevance to clinical CMV infection has not been evaluated. We analyzed samples from a cohort of solid organ transplant patients with CMV disease (n = 245) for viral microRNA expression. Several CMV microRNAs were readily detectable in patients with CMV disease in variable relative abundance. Expression level generally correlated with DNA viral load and the absence of viral microRNA wa ...[more]

PMID: 25833298

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Dataset Information

RNA-Induced Silencing Complex-associated RNA in MRC-5 cells transfected with hcmv-miR-UL22A-5p

Publications

Hcmv-miR-UL22A-5p: A Biomarker in Transplantation With Broad Impact on Host Gene Expression and Potential Immunological Implications.

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