Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

A combined genomic approach unveils the transcriptional basis of heterogeneity of human pancreatic ductal adenocarcinoma.


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Chiara Balestrieri 

PROVIDER: E-GEOD-64560 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Dissection of transcriptional and cis-regulatory control of differentiation in human pancreatic cancer.

Diaferia Giuseppe R GR   Balestrieri Chiara C   Prosperini Elena E   Nicoli Paola P   Spaggiari Paola P   Zerbi Alessandro A   Natoli Gioacchino G  

The EMBO journal 20160114 6


The histological grade of carcinomas describes the ability of tumor cells to organize in differentiated epithelial structures and has prognostic and therapeutic impact. Here, we show that differential usage of the genomic repertoire of transcriptional enhancers leads to grade-specific gene expression programs in human pancreatic ductal adenocarcinoma (PDAC). By integrating gene expression profiling, epigenomic footprinting, and loss-of-function experiments in PDAC cell lines of different grade,  ...[more]

Similar Datasets

2016-01-18 | E-GEOD-64558 | biostudies-arrayexpress
2016-04-01 | E-GEOD-12159 | biostudies-arrayexpress
2018-01-24 | E-MTAB-6005 | biostudies-arrayexpress
2018-11-02 | E-MTAB-7029 | biostudies-arrayexpress
2011-11-24 | E-GEOD-33892 | biostudies-arrayexpress
2014-09-01 | E-GEOD-59058 | biostudies-arrayexpress
2013-04-10 | E-GEOD-44158 | biostudies-arrayexpress
2014-09-01 | E-GEOD-59008 | biostudies-arrayexpress
2018-01-24 | E-MTAB-6006 | biostudies-arrayexpress
2013-04-05 | E-MTAB-1177 | biostudies-arrayexpress