Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Chiara Balestrieri
PROVIDER: E-GEOD-64560 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Diaferia Giuseppe R GR Balestrieri Chiara C Prosperini Elena E Nicoli Paola P Spaggiari Paola P Zerbi Alessandro A Natoli Gioacchino G
The EMBO journal 20160114 6
The histological grade of carcinomas describes the ability of tumor cells to organize in differentiated epithelial structures and has prognostic and therapeutic impact. Here, we show that differential usage of the genomic repertoire of transcriptional enhancers leads to grade-specific gene expression programs in human pancreatic ductal adenocarcinoma (PDAC). By integrating gene expression profiling, epigenomic footprinting, and loss-of-function experiments in PDAC cell lines of different grade, ...[more]