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Zinc Finger Protein 407 (ZFP407) Regulates Insulin-Stimulated Glucose Uptake and Glucose Transporter 4 (Glut4) mRNA

ABSTRACT: Using RNA-Seq, we compared the transcriptomes of differentiated 3T3-L1 adipocytes for control and ZFP407-deficient cells Differentiated 3T3-L1 cells were electroporated with control or 1 of 2 Zfp407 siRNAs. Six independent siRNA electroporations were conducted for the control siRNA and 3 independent electroporations were conducted for each Zfp407 siRNA.

ORGANISM(S): Mus musculus

SUBMITTER: David Buchner 

PROVIDER: E-GEOD-64757 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA.

Buchner David A DA   Charrier Alyssa A   Srinivasan Ethan E   Wang Li L   Paulsen Michelle T MT   Ljungman Mats M   Bridges Dave D   Saltiel Alan R AR  

The Journal of biological chemistry 20150116 10

The glucose transporter GLUT4 facilitates insulin-stimulated glucose uptake in peripheral tissues including adipose, muscle, and heart. GLUT4 function is impaired in obesity and type 2 diabetes leading to hyperglycemia and an increased risk of cardiovascular disease and neuropathy. To better understand the regulation of GLUT4 function, a targeted siRNA screen was performed and led to the discovery that ZFP407 regulates insulin-stimulated glucose uptake in adipocytes. The decrease in insulin-stim  ...[more]

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