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Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer

ABSTRACT: We perform RNA-seq on matched orthotopic murine primary and metastatic prostate cancer samples to identify differential gene expressions RNA-seq was performed on orthotopic murine primary and metastatic tumor samples using Illumina Hi-Seq 2000 platform

ORGANISM(S): Mus musculus

SUBMITTER: Qiang Hu

PROVIDER: E-GEOD-64771 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer.

Kirk Jason S JS Schaarschuch Kevin K Dalimov Zafardjan Z Lasorsa Elena E Ku ShengYu S Ramakrishnan Swathi S Hu Qiang Q Azabdaftari Gissou G Wang Jianmin J Pili Roberto R Ellis Leigh L

Oncotarget 20150201 5

Progression of aggressive prostate cancers (PCa) with androgen receptor splice variants or neuroendrocrine features is currently untreatable in the clinic. Therefore novel therapies are urgently required. We conducted RNA-seq using tumors from a unique murine transplant mouse model which spontaneously progresses to metastatic disease. Differential gene expression analysis revealed a significant increase of topoisomerase IIα, Top2a (Top2a) in metastatic tumors. Interrogation of human data reveale ...[more]

PMID: 25605014

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