Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Enrique Mesri
PROVIDER: E-GEOD-6482 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mutlu Agata D'Agostino AD Cavallin Lucas E LE Vincent Loïc L Chiozzini Chiara C Eroles Pilar P Duran Elda M EM Asgari Zahra Z Hooper Andrea T AT La Perle Krista M D KM Hilsher Chelsey C Gao Shou-Jiang SJ Dittmer Dirk P DP Rafii Shahin S Mesri Enrique A EA
Cancer cell 20070301 3
Transfection of a Kaposi's sarcoma (KS) herpesvirus (KSHV) Bacterial Artificial Chromosome (KSHVBac36) into mouse bone marrow endothelial-lineage cells generates a cell (mECK36) that forms KS-like tumors in mice. mECK36 expressed most KSHV genes and were angiogenic, but they didn't form colonies in soft agar. In nude mice, mECK36 formed KSHV-harboring vascularized spindle cell sarcomas that were LANA+/podoplanin+, overexpressed VEGF and Angiopoietin ligands and receptors, and displayed KSHV and ...[more]