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Transcription profiling of mouse mECK36: a cell and animal model of virally induced Kaposis sarcoma


ABSTRACT: Transfection of a Kaposi's sarcoma (KS) herpesvirus (KSHV) Bacterial Artificial Chromosome (KSHVBac36) into mouse bone marrow endothelial lineage cells generated a cell (mECK36) that induced KS-like tumors in mice. mECK36 formed KSHV-harboring vascularized spindle-cell sarcomas that were LANA+ and displayed a KSHV and host transcriptomes reminiscent of KS tumors. Experiment Overall Design: There are three biological replicates per sample. Tumors (mKS) were compared the the human KS signature. mECK36 and mEC-V were compared to putative BM lineage cells.

ORGANISM(S): Mus musculus

SUBMITTER: Enrique Mesri 

PROVIDER: E-GEOD-6482 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma.

Mutlu Agata D'Agostino AD   Cavallin Lucas E LE   Vincent Loïc L   Chiozzini Chiara C   Eroles Pilar P   Duran Elda M EM   Asgari Zahra Z   Hooper Andrea T AT   La Perle Krista M D KM   Hilsher Chelsey C   Gao Shou-Jiang SJ   Dittmer Dirk P DP   Rafii Shahin S   Mesri Enrique A EA  

Cancer cell 20070301 3


Transfection of a Kaposi's sarcoma (KS) herpesvirus (KSHV) Bacterial Artificial Chromosome (KSHVBac36) into mouse bone marrow endothelial-lineage cells generates a cell (mECK36) that forms KS-like tumors in mice. mECK36 expressed most KSHV genes and were angiogenic, but they didn't form colonies in soft agar. In nude mice, mECK36 formed KSHV-harboring vascularized spindle cell sarcomas that were LANA+/podoplanin+, overexpressed VEGF and Angiopoietin ligands and receptors, and displayed KSHV and  ...[more]

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