Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of primary ALL cells (B-lineage) resistant to vincristine by the MTT in vitro sensitivity assay

ABSTRACT: primary ALL cells (B- and T-lineage) resistant to vincristine by the MTT in vitro sensitivity assay

ORGANISM(S): Homo sapiens

SUBMITTER: William Evans 

PROVIDER: E-GEOD-649 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment.

Holleman Amy A   Cheok Meyling H MH   den Boer Monique L ML   Yang Wenjian W   Veerman Anjo J P AJ   Kazemier Karin M KM   Pei Deqing D   Cheng Cheng C   Pui Ching-Hon CH   Relling Mary V MV   Janka-Schaub Gritta E GE   Pieters Rob R   Evans William E WE  

The New England journal of medicine 20040801 6

<h4>Background</h4>Childhood acute lymphoblastic leukemia (ALL) is curable with chemotherapy in approximately 80 percent of patients. However, the cause of treatment failure in the remaining 20 percent of patients is largely unknown.<h4>Methods</h4>We tested leukemia cells from 173 children for sensitivity in vitro to prednisolone, vincristine, asparaginase, and daunorubicin. The cells were then subjected to an assessment of gene expression with the use of 14,500 probe sets to identify different  ...[more]

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