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Transcription profiling of human Caco-2 cells treated with conjugated linoleic acid (CLA)

ABSTRACT: The effect of CLA on gene expression in Caco-2 cells Experiment Overall Design: Caco-2 cells were treated with linoleic acid (LA; the parent and control fatty acid) trans-10, cis-12 CLA or cis-9, trans-11 CLA for 12 d.

ORGANISM(S): Homo sapiens

SUBMITTER: Eileen Frances Murphy

PROVIDER: E-GEOD-6518 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Conjugated linoleic acid alters global gene expression in human intestinal-like Caco-2 cells in an isomer-specific manner.

Murphy Eileen F EF Hooiveld Guido J GJ Muller Michael M Calogero Raffaele A RA Cashman Kevin D KD

The Journal of nutrition 20071101 11

Conjugated linoleic acid (CLA) exhibits isomer-specific effects on transepithelial calcium (Ca) transport as well as on cell growth in human intestinal-like Caco-2 cells. However, the molecular mechanisms of action are still unclear. Therefore, this study used a transcriptomic approach to help elucidate the molecular mechanisms underlying such isomer-specific effects. Caco-2 cells were treated with 80 micromol/L linoleic acid (control), 80 micromol/L trans-10, cis-12 CLA, or 80 micromol/L cis-9, ...[more]

PMID: 17951470

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Gene expression in mouse 3T3-L1 adipocyte tissue culture treated with cis-9,trans-11 conjugated linoleic acid(c9t11 CLA)

Project description:Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse 3T3-L1 adipocyte tissue culture; however cis-9, trans-11 CLA does not (this series). The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to c9t11 CLA. Their gene expression responses between 8 to 12 hr after treatment showed no gene expression changes indicative of an integrated stress response (ISR). Keywords: control/treatment time course

2008-01-11 | GSE8684 | GEO

Transcription profiling of mouse 3T3-L1 adipocyte tissue culture treated with cis-9,trans-11 conjugated linoleic acid(c9t11 CLA)

2008-06-16 | E-GEOD-8684 | biostudies-arrayexpress

Gene expression in 3T3-L1 mouse tissue (preadipocytes) treated with Trans-10,Cis-12 conjugated linoleic acid(t10c12 CLA)

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Conjugated linoleic acid (CLA) and Caco-2 cells

Project description:The effect of CLA on gene expression in Caco-2 cells Keywords: Human

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Transcription profiling of mouse 3T3-L1 tissue (preadipocytes) treated with trans-10,Cis-12 conjugated linoleic acid(t10c12 CLA)

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2008-06-20 | E-GEOD-11384 | biostudies-arrayexpress

The effect of CLA diet on liver gene expression

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Transcription profiling of mouse liver from polygenic obese line - effects of trans-10, cis-12-Conjugated linoleic acid

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2009-03-07 | E-GEOD-10865 | biostudies-arrayexpress

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