Dataset Information
Transcription profiling of human primary ALL cells (B-lineage) resistant to L-asparaginase by the MTT in vitro sensitivity assay
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: William Evans
PROVIDER: E-GEOD-654 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment.
The New England journal of medicine 20040801 6
<h4>Background</h4>Childhood acute lymphoblastic leukemia (ALL) is curable with chemotherapy in approximately 80 percent of patients. However, the cause of treatment failure in the remaining 20 percent of patients is largely unknown.<h4>Methods</h4>We tested leukemia cells from 173 children for sensitivity in vitro to prednisolone, vincristine, asparaginase, and daunorubicin. The cells were then subjected to an assessment of gene expression with the use of 14,500 probe sets to identify different ...[more]
