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Changes in global gene expression in SIN1 knock-out murine epithelial fibroblasts

ABSTRACT: RNA from wt and SIN1 knock-out MEF cell lines were compared Using affymetrix murine gene chip, the effects of SIN1 ablation on global gene transcription were assessed RNA from wild type and SIN1 knock out cells was purified and differences in gene expression between the two sets. MEFs were derived from C57BL/6 (Jacinto et. al. Cell. 2006 Oct 6;127(1):125-37. Epub 2006 Sep 7

ORGANISM(S): Mus musculus

SUBMITTER: Estela Jacinto 

PROVIDER: E-GEOD-65464 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1.

Moloughney Joseph G JG   Kim Peter K PK   Vega-Cotto Nicole M NM   Wu Chang-Chih CC   Zhang Sisi S   Adlam Matthew M   Lynch Thomas T   Chou Po-Chien PC   Rabinowitz Joshua D JD   Werlen Guy G   Jacinto Estela E  

Molecular cell 20160825 5

Highly proliferating cells are particularly dependent on glucose and glutamine for bioenergetics and macromolecule biosynthesis. The signals that respond to nutrient fluctuations to maintain metabolic homeostasis remain poorly understood. Here, we found that mTORC2 is activated by nutrient deprivation due to decreasing glutamine catabolites. We elucidate how mTORC2 modulates a glutamine-requiring biosynthetic pathway, the hexosamine biosynthesis pathway (HBP) via regulation of expression of glut  ...[more]

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