Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Nir Kfir
PROVIDER: E-GEOD-65644 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kfir Nir N Lev-Maor Galit G Glaich Ohad O Alajem Adi A Datta Arnab A Sze Siu K SK Meshorer Eran E Ast Gil G
Cell reports 20150416 4
Much remains unknown concerning the mechanism by which the splicing machinery pinpoints short exons within intronic sequences and how splicing factors are directed to their pre-mRNA targets. One probable explanation lies in differences in chromatin organization between exons and introns. Proteomic, co-immunoprecipitation, and sedimentation analyses described here indicate that SF3B1, an essential splicing component of the U2 snRNP complex, is strongly associated with nucleosomes. ChIP-seq and RN ...[more]