Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Naoya Tatsumi
PROVIDER: E-GEOD-65648 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Oncogene 20150511 8
The Wilms' tumor gene WT1 is overexpressed in leukemia and solid tumors and has an oncogenic role in leukemogenesis and tumorigenesis. However, precise regulatory mechanisms of WT1 overexpression remain undetermined. In the present study, microRNA-125a (miR-125a) was identified as a miRNA that suppressed WT1 expression via binding to the WT1-3'UTR. MiR-125a knockout mice overexpressed WT1, developed myeloproliferative disorder (MPD) characterized by expansion of myeloid cells in bone marrow (BM) ...[more]