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Mcl-1 is a key determinant of breast cancer cell survival

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Xin Lu

PROVIDER: E-GEOD-66072 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor.

Xiao Yu Y Nimmer Paul P Sheppard George S GS Bruncko Milan M Hessler Paul P Lu Xin X Roberts-Rapp Lisa L Pappano William N WN Elmore Steven W SW Souers Andrew J AJ Leverson Joel D JD Phillips Darren C DC

Molecular cancer therapeutics 20150526 8

Hyperexpression of antiapoptotic BCL-2 family proteins allows cells to survive despite the receipt of signals that would ordinarily induce their deletion, a facet frequently exploited by tumors. Tumors addicted to the BCL-2 family proteins for survival are now being targeted therapeutically. For example, navitoclax, a BCL-2/BCL-XL/BCL-W inhibitor, is currently in phase I/II clinical trials in numerous malignancies. However, the related family member, MCL-1, limits the efficacy of navitoclax and ...[more]

PMID: 26013319

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Mcl-1 is a key determinant of breast cancer cell survival [copy number]

Project description:Copy number profile of cultured Breast Cancer cell line measured by Affymetrix SNPs microarrays Whole genome copy number profile of 2 breast cancer cell lines were analyzed using Affymetrix SNP6.0 arrays

2015-08-07 | E-GEOD-66070 | biostudies-arrayexpress

Mcl-1 is a key determinant of breast cancer cell survival [expression]

Project description:mRNA expression profile of cultured Breast Cancer cell line measured by Affymetrix microarrays Whole genome expression profile of 32 breast cancer cell lines were analyzed with 3 biological replicates.

2015-08-07 | E-GEOD-66071 | biostudies-arrayexpress

Mcl-1 is a key determinant of breast cancer cell survival

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-08-07 | GSE66072 | GEO

Mcl-1 is a key determinant of breast cancer cell survival [expression]

Project description:mRNA expression profile of cultured Breast Cancer cell line measured by Affymetrix microarrays

2015-08-07 | GSE66071 | GEO

Mcl-1 is a key determinant of breast cancer cell survival [copy number]

Project description:Copy number profile of cultured Breast Cancer cell line measured by Affymetrix SNPs microarrays

2015-08-07 | GSE66070 | GEO

Transcriptional responses of mantle cell lymphoma (MCL) lines to IKKB inhibition

Project description:MCL cell lines were treated with DMSO or 5uM AFN700 for 20hrs This experiment is designed to see if NFKB-target genes are downregulated by inhibition of IKKB in MCL cell lines that are insensitive to ibrutinib (BTK inhibitor) or sotrastaurin (PKC inhibitor) MCL cells were seeded in 6well dishes and treated for 20hrs with DMSO or 5uM AFN700

2013-12-01 | E-GEOD-52434 | biostudies-arrayexpress

COPZ1 depletion in thyroid tumor cells triggers type-I IFN response and immunogenic cell death

Project description:Thyroid carcinoma (TC) is generally associated with good prognosis, nevertheless no effective treatments are available for aggressive forms not cured by current therapies. We previously identified the coatomer protein complex zeta 1 (COPZ1), as a new putative therapeutic target for TC, since its depletion impairs the viability of tumor cells, leads to abortive autophagy, ER stress, unfolded protein response and apoptosis, and reduces the tumor growth of TC xenograft models. In this study, by combining genomic, proteomic and functional approaches, we provided evidence that COPZ1 silencing stimulates a type I IFN-mediated viral mimicry response, boosts the production of several inflammatory molecules and finally induces immunogenic cell death, which, in turn, promotes dendritic cell maturation and subsequent activation of T cells. Collectively, our findings support the notion that COPZ1 targeting can be exploited as a new strategy to kill cancer cells with the subsequent involvement of an anti-tumor immune response.

2020-03-05 | PXD014423 | Pride

Expression and FoxA1 binding in asynchronous and mitotic HUH7 cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-03-31 | E-GEOD-39243 | biostudies-arrayexpress

A genome-wide search for epigenetically regulated genes in zebra finch using MethylCap-seq and RNA-seq

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2015-12-10 | E-GEOD-61060 | biostudies-arrayexpress

Expression data from periphereal blood lymphocytes of metastatic renal cell carcinoma patients pre and post therapy as well as 9 healthy controls

Project description:Gene expression of periphereal blood lymphocytes (PBLs) of patients with metastatic renal cell carcinoma pre and post immunotherapy was accessed and pre therapy gene expression was compared to PBL gene expression of healthy volunteers Microarray gene expression was confirmed by RT-PCR and compared to results from flow cytometry and serum cytokine analysis. PBLs of 17 patients pre therapy and 13 patients post therapy could be included in the study as well as PBLs from 9 healthy donors.

2013-02-01 | E-GEOD-34465 | biostudies-arrayexpress

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