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Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals

ABSTRACT: As a starting point for exploring potential differences in gene expression between conventional NK and FcRÎ³-NK cells, and to screen for genes that might contribute to the enhanced CD16 responsiveness of g-NK cells, we performed gene expression profiling studies on sorted samples of NK cells. NKG2C, NCR, and KIR surface receptors were used to separate FcRÎ³- NK and conventional NK cells. Indicated subsets of NK cells were sorted from 4 individual donors using a two-way sorter. RNA extracted from the sorted enriched samples were treated with Dnase and analyzed by DNA microarray (Agilent).

ORGANISM(S): Homo sapiens

SUBMITTER: Sungjin Kim

PROVIDER: E-GEOD-66124 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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