Unknown,Transcriptomics,Genomics,Proteomics

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X-CGD iPS cells before and after genome editing by designer nucleases


ABSTRACT: X-CGD (X-linked chronic granulomatous disease) patient derived CD34+ cells were reprogrammed into two X-CGD iPSC clones (7 and 25) and subsequently corrected using ZFN (clone 7) and TALEN (clone 25) by integrating a therapeutic gp91phox expression cassette into the AAVS1 "safe harbor" locus Three condition experiment: before and after reprogramming and before and after genome editing.

ORGANISM(S): Homo sapiens

SUBMITTER: Doris Steinemann 

PROVIDER: E-GEOD-66337 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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