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Expression data of T follicular helper cells (Tfh) from follicular lymphoma lymph nodes (FL) or non malignant tonsils (TONS)

ABSTRACT: GEP on Affymetrix U133+2.0 microarrays was performed on ex vivo cell-sorted Tfh from FL or TONS GEP was performed on 7 Tfh from FL and 7 Tfh from TONS

ORGANISM(S): Homo sapiens

SUBMITTER: Patricia AmÃ©-Thomas

PROVIDER: E-GEOD-66384 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells.

Amé-Thomas Patricia P Hoeller Sylvia S Artchounin Catherine C Misiak Jan J Braza Mounia Sabrina MS Jean Rachel R Le Priol Jérôme J Monvoisin Céline C Martin Nadine N Gaulard Philippe P Tarte Karin K

Blood 20150302 15

In follicular lymphoma (FL), follicular helper T cells (TFH) have been depicted as one of the main components of the malignant B-cell niche and a promising therapeutic target. Although defined by their capacity to sustain FL B-cell growth together with specific gene expression and cytokine secretion profiles, FL-TFH constitute a heterogeneous cell population. However, specific markers reflecting such functional heterogeneity are still lacking. In this study, we demonstrate that CD10 identifies a ...[more]

PMID: 25733581

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Expression data of T follicular helper cells (Tfh) from follicular lymphoma lymph nodes (FL) or non malignant tonsils (TONS)

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