Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Daisuke Okuzaki
PROVIDER: E-GEOD-66388 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Torigata Kosuke K Daisuke Okuzaki O Mukai Satomi S Hatanaka Akira A Ohka Fumiharu F Motooka Daisuke D Nakamura Shota S Ohkawa Yasuyuki Y Yabuta Norikazu N Kondo Yutaka Y Nojima Hiroshi H
PloS one 20160719 7
LATS2, a pivotal Ser/Thr kinase of the Hippo pathway, plays important roles in many biological processes. LATS2 also function in Hippo-independent pathway, including mitosis, DNA damage response and epithelial to mesenchymal transition. However, the physiological relevance and molecular basis of these LATS2 functions remain obscure. To understand novel functions of LATS2, we constructed a LATS2 knockout HeLa-S3 cell line using TAL-effector nuclease (TALEN). Integrated omics profiling of this cel ...[more]