Regulatory T cell modulation by CBP/EP300 bromodomain inhibition [array]
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Barbara Bryant
PROVIDER: E-GEOD-66596 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
Ghosh Srimoyee S Taylor Alexander A Chin Melissa M Huang Hon-Ren HR Conery Andrew R AR Mertz Jennifer A JA Salmeron Andres A Dakle Pranal J PJ Mele Deanna D Cote Alexandre A Jayaram Hari H Setser Jeremy W JW Poy Florence F Hatzivassiliou Georgia G DeAlmeida-Nagata Denise D Sandy Peter P Hatton Charlie C Romero F Anthony FA Chiang Eugene E Reimer Thornik T Crawford Terry T Pardo Eneida E Watson Venita G VG Tsui Vickie V Cochran Andrea G AG Zawadzke Laura L Harmange Jean-Christophe JC Audia James E JE Bryant Barbara M BM Cummings Richard T RT Magnuson Steven R SR Grogan Jane L JL Bellon Steve F SF Albrecht Brian K BK Sims Robert J RJ Lora Jose M JM
The Journal of biological chemistry 20160407 25
Covalent modification of histones is a fundamental mechanism of regulated gene expression in eukaryotes, and interpretation of histone modifications is an essential feature of epigenetic control. Bromodomains are specialized binding modules that interact with acetylated histones, linking chromatin recognition to gene transcription. Because of their ability to function in a domain-specific fashion, selective disruption of bromodomain:acetylated histone interactions with chemical probes serves as ...[more]
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