Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Liver gene expression profiles of interferon therapy in chronic hepatitis B Patients (mRNA)


ABSTRACT: With 350 million carriers worldwide who may suffer from serious sequelae, including hepatocellular carcinoma, chronic hepatitis B virus (CHB) infection remains an important health issue. Current antiviral therapies hardly eradicate the virus. Therefore, there are still imperative need to develop new therapeutic strategies and predictors for treatment response to cure the disease and avoid futile treatment. By taking the advantage of having the paired liver biopsy samples of IFNalpha responders before/after treatment and pretreatment samples from responders and non-responders, we could characterize the intrahepatic expression profiles associated with necroinflammatory activity and the profiles/signature potentially predictive of response to IFNalpha therapy for CHB in this study. RNA was extracted from pairedliver tissues for gene expression analysis. The gene expression profiles of seven paired liver biopsy samples of IFNalpha responders before/after treatment and other 3 pre- treatment samples were obtained by Affymatrix U133plus2 microarray. We also pooled samples of 11 responders and 11 non-responders to perform affymatrix EXON ST 1.0 array. This dataset is part of the TransQST collection.

ORGANISM(S): Homo sapiens

SUBMITTER: Tzu-Hung Hsiao 

PROVIDER: E-GEOD-66698 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Liver Gene Expression Profiles Correlate with Virus Infection and Response to Interferon Therapy in Chronic Hepatitis B Patients.

Wu Hui-Lin HL   Hsiao Tzu-Hung TH   Chen Pei-Jer PJ   Wong Siao-Han SH   Kao Jia-Horng JH   Chen Ding-Shinn DS   Lu Jo-Yang JY   Lu Tzu-Pin TP   Chen Yidong Y   Chuang Eric Y EY   Tu Hui-Chu HC   Liu Chun-Jen CJ  

Scientific reports 20160822


The natural course of chronic hepatitis B (CHB) infection and treatment response are determined mainly by the genomic characteristics of the individual. We investigated liver gene expression profiles to reveal the molecular basis associated with chronic hepatitis B and IFN-alpha (IFNα) treatment response in CHB patients. Expression profiles were compared between seven paired liver biopsy samples taken before and 6 months after successful IFNα treatment or between pretreatment biopsy samples of 1  ...[more]

Similar Datasets

2017-02-09 | GSE66699 | GEO
2017-02-09 | GSE66698 | GEO
2022-10-13 | GSE215196 | GEO
2011-03-01 | E-GEOD-27555 | biostudies-arrayexpress
2011-03-01 | GSE27555 | GEO
2018-12-26 | GSE109179 | GEO
2013-01-14 | GSE40841 | GEO
2011-07-22 | GSE23597 | GEO
2011-07-21 | E-GEOD-23597 | biostudies-arrayexpress
2011-09-02 | GSE31826 | GEO