Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Xinkun Wang
PROVIDER: E-GEOD-6693 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Xinkun X Pal Ranu R Chen Xue-wen XW Kumar Keshava N KN Kim Ok-Jin OJ Michaelis Elias K EK
Genomics 20070605 2
Neurons in the hippocampal CA1 region are particularly sensitive to oxidative stress (OS), whereas those in CA3 are resistant. To uncover mechanisms for selective CA1 vulnerability to OS, we treated organotypic hippocampal slices with duroquinone and compared transcriptional profiles of CA1 vs CA3 cells at various intervals. Gene Ontology and Biological Pathway analyses of differentially expressed genes showed that at all time points, CA1 had higher transcriptional activity for stress/inflammato ...[more]