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Array of CCR6+ ILC3 from the mesenteric lymph node of naïve C57BL/6 mice

ABSTRACT: CCR6+ innate lymphoid cells were sorted from the mesenteric lymph node of naïve C57BL/6 mice Cells were sort purified as lineage negative, CD127+ CD90.2+ CCR6+ ST2- 4 replicates were performed

ORGANISM(S): Mus musculus

SUBMITTER: Gregory Sonnenberg

PROVIDER: E-GEOD-67076 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.

Hepworth Matthew R MR Fung Thomas C TC Masur Samuel H SH Kelsen Judith R JR McConnell Fiona M FM Dubrot Juan J Withers David R DR Hugues Stephanie S Farrar Michael A MA Reith Walter W Eberl Gérard G Baldassano Robert N RN Laufer Terri M TM Elson Charles O CO Sonnenberg Gregory F GF

Science (New York, N.Y.) 20150423 6238

Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian tissue antigens, the mechanisms that control selection of commensal bacteria-specific T cells remain poorly understood. Here, we demonstrate that group 3 innate lymphoid cell (ILC3)-intrinsic expression of major histocompatibility complex class II (MH ...[more]

PMID: 25908663

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