Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human mantle cell lymphoma cell lines with inhibition of the NMD pathway

ABSTRACT: Identification of potential tumor suppressor genes using the GINI strategy in Mantle Cell Lymphoma cell lines Experiment Overall Design: Inhibition of the NMD pathway was performed in Mantle Cell Lymphoma cell lines according to a modified protocol previously described (Noensie EN et al Nat Biotechnol 2001;19:434-439; Huusko P et al, Nat Gentet 2004; 36:979-983). The cells were treated with emetine or with emetine followed by incubation with actinomycin D during a time course. Mock treated cells were used as reference.

ORGANISM(S): Homo sapiens

SUBMITTER: Pedro Jares 

PROVIDER: E-GEOD-6728 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis.

Pinyol Magda M   Bea Silvia S   Plà Laura L   Ribrag Vincent V   Bosq Jacques J   Rosenwald Andreas A   Campo Elias E   Jares Pedro P  

Blood 20070301 12

Mantle-cell lymphoma (MCL) is genetically characterized by the translocation t(11;14)(q13;q32) and a high number of secondary chromosomal abnormalities. To identify genes inactivated in this lymphoma, we examined 5 MCL cell lines following a strategy previously described in tumors with microsatellite instability that is based on the combined inhibition of the nonsense-mediated mRNA decay pathway and gene-expression profiling. This approach, together with the design of a conservative algorithm fo  ...[more]

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