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Expression data from human heart right ventricular wall

ABSTRACT: Gene expression in the right ventricle is different in control patients as compared to either idiopathic dilated cardiomyopathy or pulmonary arterial hypertension Two human hearts obtained at autopsy from each of control, pulmonary hypertension, and dilated cardiomyopathy

ORGANISM(S): Homo sapiens

SUBMITTER: James West

PROVIDER: E-GEOD-67492 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension.

Hemnes Anna R AR Brittain Evan L EL Trammell Aaron W AW Fessel Joshua P JP Austin Eric D ED Penner Niki N Maynard Karen B KB Gleaves Linda L Talati Megha M Absi Tarek T Disalvo Thomas T West James J

American journal of respiratory and critical care medicine 20140201 3

<h4>Rationale</h4>Shorter survival in heritable pulmonary arterial hypertension (HPAH), often due to BMPR2 mutation, has been described in association with impaired right ventricle (RV) compensation. HPAH animal models are insulin resistant, and cells with BMPR2 mutation have impaired fatty acid oxidation, but whether these findings affect the RV in HPAH is unknown.<h4>Objectives</h4>To test the hypothesis that BMPR2 mutation impairs RV hypertrophic responses in association with lipid deposition ...[more]

PMID: 24274756

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Expression data from human heart right ventricular wall

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