Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Long Gao
PROVIDER: E-GEOD-67609 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cai Xiongwei X Gao Long L Teng Li L Ge Jingping J Oo Zaw Min ZM Kumar Ashish R AR Gilliland D Gary DG Mason Philip J PJ Tan Kai K Speck Nancy A NA
Cell stem cell 20150709 2
The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1 mutations can be early events, creating preleukemic stem cells that expand in the bone marrow. Here we show, counterintuitively, that Runx1-deficient hematopoietic stem and progenitor cells (HSPCs) have a slow growth, low biosynthetic, small cell phenotype and markedly reduced ribosome biogenesis (Ribi). The reduced Ribi involved decreased levels of rRNA and many mRNAs encoding ribosome proteins. ...[more]