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The cytosolic iron-sulfur cluster assembly protein MMS19 regulates transcriptional gene silencing, DNA repair, and flowering time in Arabidopsis

ABSTRACT: To study how MMS19 and ABO4 affect gene expression, we performed RNA deep sequencing for the seedlings materials Col, mms19-1,and abo4 mutants. Compare the mRNA profiles of 14-day old seedlings materials of mutants (mms19-1 and abo4) to wild type Col by Illumina suquencing.

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: huanwei huang

PROVIDER: E-GEOD-67669 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Cytosolic Iron-Sulfur Cluster Assembly Protein MMS19 Regulates Transcriptional Gene Silencing, DNA Repair, and Flowering Time in Arabidopsis.

Han Yong-Feng YF Huang Huan-Wei HW Li Lin L Cai Tao T Chen She S He Xin-Jian XJ

PloS one 20150608 6

MMS19 is an essential component of the cytoplasmic iron-sulfur (Fe-S) cluster assembly complex in fungi and mammals; the mms19 null mutant alleles are lethal. Our study demonstrates that MMS19/MET18 in Arabidopsis thaliana interacts with the cytoplasmic Fe-S cluster assembly complex but is not an essential component of the complex. We find that MMS19 also interacts with the catalytic subunits of DNA polymerases, which have been demonstrated to be involved in transcriptional gene silencing (TGS), ...[more]

PMID: 26053632

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