Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sharon Dent
PROVIDER: E-GEOD-67715 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hirsch Calley L CL Coban Akdemir Zeynep Z Wang Li L Jayakumaran Gowtham G Trcka Dan D Weiss Alexander A Hernandez J Javier JJ Pan Qun Q Han Hong H Xu Xueping X Xia Zheng Z Salinger Andrew P AP Wilson Marenda M Vizeacoumar Frederick F Datti Alessandro A Li Wei W Cooney Austin J AJ Barton Michelle C MC Blencowe Benjamin J BJ Wrana Jeffrey L JL Dent Sharon Y R SY
Genes & development 20150415 8
Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory pathways. Pluripotent-specific transcriptional networks are sequentially reactivated as somatic cells reprogram to achieve pluripotency. How epigenetic regulators modulate this process and contribute to somatic cell reprogramming is not clear. Here we performed a functional RNAi screen to identify the earliest epigenetic regulators required for reprogramming. We identified components of the SAGA h ...[more]