Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcriptomic analyses of duodenum from wild type and VDR-null mice

ABSTRACT: As duodenum is an important Vitamin D target organ, transcriptomic analyses were performed in this tissue. We analysed RNA extracted from duodenum of three 10 week-old wild-type and VDR-null mice using the Affymetrix Mouse Gene 2.0 ST.

ORGANISM(S): Mus musculus

SUBMITTER: Doulaye Dembele

PROVIDER: E-GEOD-67904 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.

Huet Tiphaine T Laverny Gilles G Ciesielski Fabrice F Molnár Ferdinand F Ramamoorthy Thanuja Gali TG Belorusova Anna Y AY Antony Pierre P Potier Noelle N Metzger Daniel D Moras Dino D Rochel Natacha N

Cell reports 20150122 4

The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). The 3D structures of the VDR ligand-binding domain with 1,25(OH)2D3 or gemini analogs unveiled the molecular mechanism underlying ligand recognition. On the basis of structure-function correlations, we generated a point-mutated VDR (VDR(gem)) that is unresponsive to 1,25(OH)2D3, but the activity ...[more]

PMID: 25620699

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Dataset Information

Transcriptomic analyses of duodenum from wild type and VDR-null mice

Publications

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.

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