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CpG island methylation data from maternal venous blood and infant cord blood samples

ABSTRACT: The biological mechanism of cadmium's effects is poorly characterized. This data was generated in order to help better understand the epigenetic role that Cadmium plays. We used the MIRA assay and the Affymetrix Human Promoter 1.0R Array in order to measure methylation levels in promoter regions. 34 samples corresponding to 17 mother-infant pairs were selected based upon measured levels of cadmium in the blood. Methylated DNA fragments were then isolated, amplified, and run on the Affymetrix Human Promoter 1.0R Array. Results were then summarized to CpG islands for each sample.

ORGANISM(S): Homo sapiens

SUBMITTER: Saideep Gona 

PROVIDER: E-GEOD-67976 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs.

Sanders Alison P AP   Smeester Lisa L   Rojas Daniel D   DeBussycher Tristan T   Wu Michael C MC   Wright Fred A FA   Zhou Yi-Hui YH   Laine Jessica E JE   Rager Julia E JE   Swamy Geeta K GK   Ashley-Koch Allison A   Lynn Miranda Marie M   Fry Rebecca C RC  

Epigenetics 20131028 2

Cadmium (Cd) is prevalent in the environment yet understudied as a developmental toxicant. Cd partially crosses the placental barrier from mother to fetus and is linked to detrimental effects in newborns. Here we examine the relationship between levels of Cd during pregnancy and 5-methylcytosine (5mC) levels in leukocyte DNA collected from 17 mother-newborn pairs. The methylation of cytosines is an epigenetic mechanism known to impact transcriptional signaling and influence health endpoints. A m  ...[more]

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