Identification of targets for rational pharmacological therapy in childhood craniopharyngioma

ABSTRACT: Introduction: Pediatric adamantinomatous craniopharyngioma (ACP) is a histologically benign but clinically aggressive brain tumor that arises from the sellar/suprasellar region. Despite a high survival rate with current surgical and radiation therapy (75-95% at 10 years), ACP is associated with debilitating visual, endocrine, neurocognitive and psychological morbidity, resulting in exceptionally poor quality of life for survivors. Identification of an effective pharmacological therapy would drastically decrease morbidity and improve long term outcomes for children with ACP. Results: Using microarray analysis of 15 ACP patient samples, we have found several pharmaceutical targets that are significantly and consistently overexpressed in our panel of ACP relative to other pediatric brain tum

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Donson 

PROVIDER: E-GEOD-68015 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress