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Bowel miRNA expression profiles of infants with gastrointestinal conditions

ABSTRACT: We have employed miRNA microarray expression profiling to identify miRNA differentially expressed in neonatal bowel tissues with different gastrointestinal conditions. Bowel tissues were collected from infants who underwent surgery treatment for necrotizing enterocolitis (NEC), spontaneous intestinal perforation (SIP). Infants with other non-inflammatory, congenital intestinal conditions were employed as the Surgical-Control. Differential miRNA microarray analysis was performed.

ORGANISM(S): Homo sapiens

SUBMITTER: Kathy Chan

PROVIDER: E-GEOD-68054 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comparative MiRNA Expressional Profiles and Molecular Networks in Human Small Bowel Tissues of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation.

Ng Pak Cheung PC Chan Kathy Yuen Yee KY Leung Kam Tong KT Tam Yuk Him YH Ma Terence Ping Yuen TP Lam Hugh Simon HS Cheung Hon Ming HM Lee Kim Hung KH To Ka Fai KF Li Karen K

PloS one 20150814 8

<h4>Background</h4>Necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) are acute intestinal conditions which could result in mortality and severe morbidity in preterm infants. Our objective was to identify dysregulated micro-RNAs (miRNAs) in small bowel tissues of NEC and SIP, and their possible roles in disease pathophysiology.<h4>Methods</h4>We performed differential miRNA arrays on tissues of NEC (n = 4), SIP (n = 4) and surgical-control (Surg-CTL; n = 4), and validat ...[more]

PMID: 26274503

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Bowel expression profiles of infants with gastrointestinal conditions

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