Unknown,Transcriptomics,Genomics,Proteomics

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Anterior Heart Field (AHF)-conditional Mef2c Knockout


ABSTRACT: We have performed conditional inactivation of mef2c in the anterior heart field (AHF) of mice and observed a phenotypic spectrum of outflow tract anomalies in the conditional mutant hearts. In an effort to identify misregulated genes in the outflow tracts of the mutants, we have performed RNA-Seq on outflow tract samples dissected from E10.5 mutant and wild-type embryos. There are four wild-type samples and four mutant samples.

ORGANISM(S): Mus musculus

SUBMITTER: Brian Black 

PROVIDER: E-GEOD-68147 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1.

Barnes Ralston M RM   Harris Ian S IS   Jaehnig Eric J EJ   Sauls Kimberly K   Sinha Tanvi T   Rojas Anabel A   Schachterle William W   McCulley David J DJ   Norris Russell A RA   Black Brian L BL  

Development (Cambridge, England) 20160125 5


Congenital heart defects are the most common birth defects in humans, and those that affect the proper alignment of the outflow tracts and septation of the ventricles are a highly significant cause of morbidity and mortality in infants. A late differentiating population of cardiac progenitors, referred to as the anterior second heart field (AHF), gives rise to the outflow tract and the majority of the right ventricle and provides an embryological context for understanding cardiac outflow tract a  ...[more]

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