Dataset Information
Transcription profiling of mouse NIH3T3 cells over-expressing RNA-dependent serine/threonine protein kinase (PKR)PKR
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Rob Sladek
PROVIDER: E-GEOD-682 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The protein kinase PKR: a molecular clock that sequentially activates survival and death programs.
The EMBO journal 20040129 3
Cell death and survival play a key role in the immune system as well as during development. The control mechanisms that balance cell survival against cell death are not well understood. Here we report a novel strategy used by a single protein to regulate chronologically cell survival and death. The interferon-induced protein kinase PKR acts as a molecular clock by using catalysis-dependent and -independent activities to temporally induce cell survival prior to cell death. We show that the proapo ...[more]
