Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Riccardo Dalla-Favera
PROVIDER: E-GEOD-68349 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Dominguez-Sola David D Kung Jennifer J Holmes Antony B AB Wells Victoria A VA Mo Tongwei T Basso Katia K Dalla-Favera Riccardo R
Immunity 20151124 6
The pathways regulating formation of the germinal center (GC) dark zone (DZ) and light zone (LZ) are unknown. In this study we show that FOXO1 transcription factor expression was restricted to the GC DZ and was required for DZ formation, since its absence in mice led to the loss of DZ gene programs and the formation of LZ-only GCs. FOXO1-negative GC B cells displayed normal somatic hypermutation but defective affinity maturation and class switch recombination. The function of FOXO1 in sustaining ...[more]