Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of chicken male and female embryonic brains (arnol-affy-chick-345142)

ABSTRACT: The study is relevant to an understanding of the forces that lead to sex differences in the brain. Many neural and psychiatric diseases affect men and women differently, so the understanding of sex differences in brain function impacts on our understanding of why the male and female brain differ in their susceptibility to disease. Using Affymetrix chicken arrays, we will measure the gene expression in male and female embryonic chicken brain. Gene expression differs in the male and female embryonic chicken brain. 20 male and 20 female chicken embryos will serve as source of brain tissue. In late stage embryos, we will remove the brain tissue and extract total RNA. Four birds will comprise each individual sample. Thus, we will have 5 biologically independent male samples, and an equal number of female samples.

ORGANISM(S): Gallus gallus

SUBMITTER: Elizabeth Salomon 

PROVIDER: E-GEOD-6844 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Background</h4>In animals with heteromorphic sex chromosomes, dosage compensation of sex-chromosome genes is thought to be critical for species survival. Diverse molecular mechanisms have evolved to effectively balance the expressed dose of X-linked genes between XX and XY animals, and to balance expression of X and autosomal genes. Dosage compensation is not understood in birds, in which females (ZW) and males (ZZ) differ in the number of Z chromosomes.<h4>Results</h4>Using microarray analy  ...[more]