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Transcription profiling of human immature dendritic cells under hypoxic condition

ABSTRACT: Dendritic cells (DCs) are professional antigen-presenting cells whose activity is intrinsically linked to the microenvironment. Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues that creates a special microenvironment conditioning cell physiology. We studied the effects of hypoxia on the differentiation of human monocytes into DCs. Immature DCs were differentiated in vitro from human monocytes under normoxic (iDCs) or hypoxic (Hi-DCs) conditions and the gene expression profile was determined. Hi-DCs expressed novel hypoxia-inducible genes and were characterized by up-regulation of pathways associated with cell movement/migration. Experiment Overall Design: The expression profile of immature dendritic cells under normoxia vs hypoxia was studied. Three healthy donors were used as biologial replicates.

ORGANISM(S): Homo sapiens

SUBMITTER: Paolo Fardin 

PROVIDER: E-GEOD-6863 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptome of hypoxic immature dendritic cells: modulation of chemokine/receptor expression.

Ricciardi Annamaria A   Elia Angela Rita AR   Cappello Paola P   Puppo Maura M   Vanni Cristina C   Fardin Paolo P   Eva Alessandra A   Munroe David D   Wu Xiaolin X   Giovarelli Mirella M   Varesio Luigi L  

Molecular cancer research : MCR 20080201 2

Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues. Dendritic cells (DC) are professional antigen-presenting cells whose differentiation, migration, and activities are intrinsically linked to the microenvironment. DCs will home and migrate through pathologic tissues before reaching their final destination in the lymph node. We studied the differentiation of human monocytes into immature DCs (iDCs) in a hypoxic microenvironment. We generated iDC in vitro under normoxic  ...[more]

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