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Transcription profiling of mouse Notch1 deficient in hair follicles

ABSTRACT: Notch1 deficient hair matrix keratinocytes have lower mitotic rates, resulting in smaller follicles with fewer cells. In addition, the ratio of melanocytes to keratinocytes is greatly reduced. Microarray was performed to study downstream mechanism of Notch1-deficiency Experiment Overall Design: Microarray was first performed using HF_emN1-1 and HF_anN1-1 samples. Later, HF_emN1-2, HF_anN1-2, HF_WT-1, and HF_WT-2 were used to perform another set of microarray. anN1s and WTs were used as wild-type controls.

ORGANISM(S): Mus musculus

SUBMITTER: Raphael Kopan 

PROVIDER: E-GEOD-6867 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes.

Lee Jonghyeob J   Basak Jacob M JM   Demehri Shadmehr S   Kopan Raphael R  

Development (Cambridge, England) 20070704 15

Notch1-deficient epidermal keratinocytes become progressively hyperplastic and eventually produce tumors. By contrast, Notch1-deficient hair matrix keratinocytes have lower mitotic rates, resulting in smaller follicles with fewer cells. In addition, the ratio of melanocytes to keratinocytes is greatly reduced in hair follicles. Investigation into the underlying mechanism for these phenotypes revealed significant changes in the Kit, Tgfbeta and insulin-like growth factor (IGF) signaling pathways,  ...[more]

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